TOP RESEARCH MEMBERS CONTACT PUBLICATIONS

JA LAB

Investigating the ABCs of Drosophila:
Aging, Behavior, and (mi)Crobes

ABCs of Drosophila

Research Focus

Over a century of research on the fruit fly has resulted in profound discoveries in basic cellular processes, and has enabled the use of Drosophila as a model for human disease and drug discovery. Our laboratory uses diverse tools in chemistry and biology to dissect genetic pathways and neural circuitry involved in aging, behavior, and disease. We are currently involved in several projects including:


1. Interactions of symbiotic microorganisms with Drosophila

Fly-associated microbes can promote host longevity and development. Using the powerful genetic tools available for manipulating Drosophila, we are investigating the molecular mechanisms required for maintaining relationships between the fly microbiome, nutrition, and host physiology and health.


2. Aging and nutrition

We have identified genes that modify lifespan in response to environmental cues, including temperature and nutrient availability. The mechanistic analysis of these genetic pathways includes application of large-scale methods (metabolomics, lipidomics) and gene expression studies on Drosophila mutants. We are also investigating small molecule-modulators of mitochondrial function in cell culture models of aging.


3. Drosophila feeding behavior

The analysis of hunger, satiety, and the timing of meals has been neglected, despite the possible role played by prandial habits in obesity, hypercholesterolemia, and diabetes. We are 1) developing simple tools for measuring short- and long-term food consumption in flies and 2) characterizing genetic and neural manipulations that affect feeding behavior. This work will provide a better understanding of the central mechanisms that underlie appetite and feeding behavior at the genetic and neuronal levels.


4. Interaction between feeding and sleep

Eating and sleeping are fundamental behaviors that are critical to survival. Increasing evidence suggests that the processes regulating these behaviors are linked. We have developed the Activity Recording CAFE (ARC) for assessing both food intake and sleep in individually housed adult flies (Murphy et al. (2017) Nat. Protoc.). With the ARC, we are dissecting the sleep-feeding axis in Drosophila and have identified mechanisms that regulate postprandial sleep (Murphy et al. (2016) eLife).

The ARC provides a simple, inexpensive, and customizable platform for studying animal behavior using webcams and 3-D printed chambers. For questions on adapting the ARC for your studies, please don’t hesitate to contact us or refer to the ARC GitHub repository or the FAQ page.

LAB MEMBERS

The Ja Lab Team


Current members

William Ja

William Ja

Associate Professor

Education:
B.S., Chemistry, University of California, Berkeley, 1998
Ph.D., Chemistry, California Institute of Technology, 2004
Postdoc, Biology, California Institute of Technology, 2005-2009

Faculty Page

Erin Keebaugh

Erin Keebaugh

Postdoctoral Research Associate

Education:
B.S., Genetics, University of Georgia, Athens, GA, 2004
Ph.D., Population Biology, Ecology, and Evolution, Emory University, 2013

Scarlet Park

Scarlet (Jinhong) Park

Graduate Student

Education:
B.A., Psychology, Carleton College, Northfield, MN, 2015

Dane Wiren

Dane Wiren

Education:
Biotech Program, Palm Beach State College, 2011-Present
Psychology & Music, Knox College, 1988-1990

Ashley Stanisclasse

Ashley Stanisclasse

Undergraduate Intern

Education:
Florida Atlantic University, Harriet L. Wilkes Honors College

Anita Nwiloh

Anita Nwiloh

Undergraduate Intern

Education:
Florida Atlantic University, Harriet L. Wilkes Honors College

JaBot

Mini-Ja

The Robot Overlord from Wi-Fi

I haz eyes. I haz ears. I haz voice.

Famous quotes:

"Pick me up! Show me your western!"

"Why are you still here? Go home!"



Collaborators

Ken Dawson-Scully

Ken Dawson-Scully

Assistant Professor
Department of Biological Sciences
Florida Atlantic University

Education:
Ph.D., University of Toronto, Canada, 2003

Faculty Page



Past Members

Yaa Abu
Suzanne Al-Said
Justin Archer
Paige Beckey
Kim Bruce (Assistant Professor, University of Colorado)
Ilaria Drago
Margaux Ehrlich
Max Fisch
Heather Gilchrest
Adwait Godbole
Stephanie Heung
Sany Hoxha
Laura Kuperman
Alex McBee
Keith Murphy
Alina Soto Obando
Shivani Patel
Angela Phillips (Ph.D. student, MIT)
Stefan Ragnarsson
Cathy Ray
Tania Rodriguez
Sarah Rollins
Diana Singkornrat
Chenchen Su
Alianis Tirado
Nicolas Tran
Cathy Trivigno (Instructor, Florida Atlantic University)
Li-Jie Wang
Chris Warner
Jennifer Weissbach
Daniel Whu
Leslie Williams
Ryuichi Yamada (Visiting Fellow, University of Tokyo)

 

POSITIONS IN THE LAB

Postdoctoral candidates interested in joining our laboratory should send a cover letter, CV, and contact information for references to Ms. Alex James (ajames@scripps.edu).

Prospective graduate students should apply directly to the Skaggs Graduate School.
Current Scripps graduate students should contact Prof. Ja directly to discuss rotation projects.

CONTACT

Scripps Florida Jupiter
Jupiter Lighthouse

William W. Ja, Ph.D.

Associate Professor
Department of Neuroscience
The Scripps Research Institute, Florida
130 Scripps Way, 3B3
Jupiter, FL 33458

Ms. Alex James

Administrative Assistant
Department of Neuroscience
The Scripps Research Institute, Florida
130 Scripps Way, 3B3
Jupiter, FL 33458
(561) 228-2272
ajames@scripps.edu